Publications

Check out our recent publications!

  • Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway

    Nature & Structural Molecular Biology (2026)

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  • GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade

    PLOS Biology (2024)

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  • A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

    Nature Structural and Molecular Biology (2022)

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  • Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

    PLOS Biology (2021)

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  • Smoothened stimulation by membrane sterols drives Hedgehog pathway activation

    Nature (2019)

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Key Publications

  • Steiner, W. P.; Iverson, N.; Liu, G.; Venkatakrishnan, V.; Wu, J.; Stepniewski, T. M.; Michaelson, Z.; Bröckel, J. W.; Zhu, J.-F.; Bruystens, J. G. H.; Lee, A.; Nelson, I.; Bertinetti, D.; Arveseth, C. D.; Tan, G.; Spaltenstein, P.; Xu, J.; Hüttenhain, R.; Kay, M. S.; Herberg, F. W.; Cao, E.; Selent, J.; Anand, G. S.; Dunbrack, R. L.; Taylor, S. S.; Myers, B. R. Structural Mechanism for Noncanonical GPCR Signaling in the Hedgehog Pathway. Nat. Struct. Mol. Biol. 2026, 33 (5), 795–809. https://doi.org/10.1038/s41594-026-01800-z.

  • Hilgendorf, K. I.; Myers, B. R.; Reiter, J. F. Emerging Mechanistic Understanding of Cilia Function in Cellular Signalling. Nat. Rev. Mol. Cell Biol. 2024. https://doi.org/10.1038/s41580-023-00698-5.

  • Casey, M. J.; Chan, P. P.; Li, Q.; Zu, J.-F.; Jette, C. A.; Kohler, M.; Myers, B. R.; Stewart, R. A. A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma. Cell Rep. 2024, 43 (8), 114559. https://doi.org/10.1016/j.celrep.2024.114559.

  • Walker, M. F.; Zhang, J.; Steiner, W.; Ku, P.-I.; Zhu, J.-F.; Michaelson, Z.; Yen, Y.-C.; Lee, A.; Long, A. B.; Casey, M. J.; Poddar, A.; Nelson, I. B.; Arveseth, C. D.; Nagel, F.; Clough, R.; LaPotin, S.; Kwan, K. M.; Schulz, S.; Stewart, R. A.; Tesmer, J. J. G.; Caspary, T.; Subramanian, R.; Ge, X.; Myers, B. R. GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade.PLOS Biol. 2024, 22 (8), e3002685. https://doi.org/10.1371/journal.pbio.3002685.

  • Happ, J. T.; Arveseth, C. D.; Bruystens, J.; Bertinetti, D.; Nelson, I. B.; Olivieri, C.; Zhang, J.; Hedeen, D. S.; Zhu, J.-F.; Capener, J. L.; Bröckel, J. W.; Vu, L.; King, C. C.; Ruiz-Perez, V. L.; Ge, X.; Veglia, G.; Herberg, F. W.; Taylor, S. S.; Myers, B. R. A PKA Inhibitor Motif within SMOOTHENED Controls Hedgehog Signal Transduction. Nat. Struct. Mol. Biol. 2022, 29 (10), 990–999. https://doi.org/10.1038/s41594-022-00838-z.

  • Arveseth, C. D.; Happ, J. T.; Hedeen, D. S.; Zhu, J.-F.; Capener, J. L.; Klatt Shaw, D.; Deshpande, I.; Liang, J.; Xu, J.; Stubben, S. L.; Nelson, I. B.; Walker, M. F.; Kawakami, K.; Inoue, A.; Krogan, N. J.; Grunwald, D. J.; Hüttenhain, R.; Manglik, A.; Myers, B. R. Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits. PLOS Biol. 2021, 19 (4), e3001191. https://doi.org/10.1371/journal.pbio.3001191.

  • Deshpande, I.; Liang, J.; Hedeen, D.; Roberts, K. J.; Zhang, Y.; Ha, B.; Latorraca, N. R.; Faust, B.; Dror, R. O.; Beachy, P. A.; Myers, B. R.; Manglik, A. Smoothened Stimulation by Membrane Sterols Drives Hedgehog Pathway Activity.Nature 2019, 571 (7764), 284–288. https://doi.org/10.1038/s41586-019-1355-4.

  • Myers, B. R.; Neahring, L.; Zhang, Y.; Roberts, K. J.; Beachy, P. A. Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.PNAS 2017, 114 (52) E11141-E11150. https://doi.org/10.1073/pnas.1717891115.

  • Sweeney, R. T.; McClary, A. C.; Myers, B. R.; Biscocho, J.; Neahring, L.; Kwei, K. A.; Qu, K.; Gong, X.; Ng, T.; Jones, C. D.; Varma, S.; Odegaard, J. I.; Sugiyama, T.; Koyota, S.; Rubin, B. P.; Troxell, M. L.; Pelham, R. J.; Zehnder, J. L.; Beachy, P. A.; Pollack, J. R.; West, R. B. Identification of Recurrent SMO and BRAF Mutations in Ameloblastomas.Nat. Genet. 2014, 46 (7), 722–725. https://doi.org/10.1038/ng.2986.

  • Myers, B. R.; Sever, N.; Chong, Y. C.; Kim, J.; Belani, J. D.; Rychnovsky, S.; Bazan, J. F.; Beachy, P. A. Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response.Dev. Cell 2013, 26 (4), 346–357. https://doi.org/10.1016/j.devcel.2013.07.015.

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